Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery

Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was ai...

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Tác giả chính:	Hoang, Nhan Hoa, Hoang Hao, Le, Thien Giap, Le
Định dạng:	Bài trích
Ngôn ngữ:	English
Thông tin xuất bản:	Elsevier 2022
Chủ đề:	Hydroxyethyl cellulose Solid lipid nanoparticle
Truy cập trực tuyến:	https://www.sciencedirect.com/science/article/abs/pii/S0141813021025678?via%3Dihub https://dlib.phenikaa-uni.edu.vn/handle/PNK/5876 https://doi.org/10.1016/j.ijbiomac.2021.11.161
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spelling	oai:localhost:PNK-58762022-08-17T05:54:54Z Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery Hoang, Nhan Hoa Hoang Hao, Le Thien Giap, Le Hydroxyethyl cellulose Solid lipid nanoparticle Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was aimed to develop hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in solid lipid nanoparticles (SLNs), and to enhance the antimicrobial activity of MTZ. SLNs were prepared using a combination method of solvent evaporation and hot homogenization. The results showed that the fabricated SLNs, comprising of Precirol (2.93%, w/v), Tween 80 (1.8%, w/v), and the drug:lipid ratio of 19.3% (w/w), were approximately 200 nm in size, with a narrow distribution. The HEC (3%, w/w)-based gel formed a smooth, homogeneous structure and had preferable mechanical and rheological properties. Moreover, the MTZ-loaded SLNs-based HEC gel (equivalent to 1% of MTZ, w/w) exhibited a sustained in vitro drug release pattern, optimal ex vivo permeability, and enhanced in vitro antimicrobial activity after 24 h of treatment. These findings indicate the potential of the MTZ-loaded SLNs-based HEC formulation for local drug delivery at the buccal mucosa in managing periodontal disease. 2022-07-13T01:59:47Z 2022-07-13T01:59:47Z 2022 Bài trích https://www.sciencedirect.com/science/article/abs/pii/S0141813021025678?via%3Dihub https://dlib.phenikaa-uni.edu.vn/handle/PNK/5876 https://doi.org/10.1016/j.ijbiomac.2021.11.161 en Elsevier
institution	Trường Đại học Phenikaa
collection	DSpace
language	English
topic	Hydroxyethyl cellulose Solid lipid nanoparticle
spellingShingle	Hydroxyethyl cellulose Solid lipid nanoparticle Hoang, Nhan Hoa Hoang Hao, Le Thien Giap, Le Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
description	Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was aimed to develop hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in solid lipid nanoparticles (SLNs), and to enhance the antimicrobial activity of MTZ. SLNs were prepared using a combination method of solvent evaporation and hot homogenization. The results showed that the fabricated SLNs, comprising of Precirol (2.93%, w/v), Tween 80 (1.8%, w/v), and the drug:lipid ratio of 19.3% (w/w), were approximately 200 nm in size, with a narrow distribution. The HEC (3%, w/w)-based gel formed a smooth, homogeneous structure and had preferable mechanical and rheological properties. Moreover, the MTZ-loaded SLNs-based HEC gel (equivalent to 1% of MTZ, w/w) exhibited a sustained in vitro drug release pattern, optimal ex vivo permeability, and enhanced in vitro antimicrobial activity after 24 h of treatment. These findings indicate the potential of the MTZ-loaded SLNs-based HEC formulation for local drug delivery at the buccal mucosa in managing periodontal disease.
format	Bài trích
author	Hoang, Nhan Hoa Hoang Hao, Le Thien Giap, Le
author_facet	Hoang, Nhan Hoa Hoang Hao, Le Thien Giap, Le
author_sort	Hoang, Nhan Hoa
title	Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_short	Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_full	Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_fullStr	Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_full_unstemmed	Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_sort	formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
publisher	Elsevier
publishDate	2022
url	https://www.sciencedirect.com/science/article/abs/pii/S0141813021025678?via%3Dihub https://dlib.phenikaa-uni.edu.vn/handle/PNK/5876 https://doi.org/10.1016/j.ijbiomac.2021.11.161
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Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery

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