Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea
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| Định dạng: | Bài trích |
| Ngôn ngữ: | English |
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Biomolecules
2021
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| Truy cập trực tuyến: | https://www.mdpi.com/2218-273X/11/5/723 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1852 https://doi.org/10.3390/biom11050723 |
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oai:localhost:PNK-18522022-08-17T05:54:42Z Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea Orfanoudaki, Maria Hartmann, Anja Alilou, Mostafa Mehic, Naida Kwiatkowski, Marcel Jöhrer, Karin Nguyen, Ngoc Hieu Hensel, Andreas Greil, Richard Ganzera, Markus antimicrobial agents cytotoxicity prenylated hydroquinones brominated compounds Q1 The class of demosponges is the biggest and most diverse of all described sponge species and it is reported to produce a plethora of chemically different metabolites with interesting biological activities. The focus of the present study was to investigate the chemical composition of two Mediterranean demosponges, targeting their brominated compounds and prenylated hydroquinones, compounds with interesting cytotoxic and anti-microbial properties. In order to gain a deeper insight into the chemical diversity of their metabolites and their activities, 20 pure secondary metabolites including new natural products were isolated from two different species (Aplysina aerophoba and Spongia sp.) using various chromatographic techniques. Their structures were confirmed by NMR and HRMS, revealing molecules with various chemical scaffolds, mainly prenylated hydroquinones from Spongia sp. and halogenated compounds from Aplysina aerophoba, including 5 novel natural products. The isolated compounds were investigated for their cytotoxic properties using 9 different cell lines, and especially one compound, 2,6-dibromo-4-hydroxy-4-methoxycarbonylmethylcyclohexa-2,5-dien-1-one showed good activities in all tested models. 2021-06-18T02:50:02Z 2021-06-18T02:50:02Z 2021 Article Working Paper https://www.mdpi.com/2218-273X/11/5/723 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1852 https://doi.org/10.3390/biom11050723 en application/pdf Biomolecules |
| institution |
Trường Đại học Phenikaa |
| collection |
DSpace |
| language |
English |
| topic |
antimicrobial agents cytotoxicity prenylated hydroquinones brominated compounds |
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antimicrobial agents cytotoxicity prenylated hydroquinones brominated compounds Orfanoudaki, Maria Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea |
| description |
Q1 |
| author2 |
Hartmann, Anja |
| author_facet |
Hartmann, Anja Orfanoudaki, Maria |
| format |
Article |
| author |
Orfanoudaki, Maria |
| author_sort |
Orfanoudaki, Maria |
| title |
Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea |
| title_short |
Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea |
| title_full |
Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea |
| title_fullStr |
Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea |
| title_full_unstemmed |
Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea |
| title_sort |
cytotoxic compounds of two demosponges (aplysina aerophoba and spongia sp.) from the aegean sea |
| publisher |
Biomolecules |
| publishDate |
2021 |
| url |
https://www.mdpi.com/2218-273X/11/5/723 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1852 https://doi.org/10.3390/biom11050723 |
| work_keys_str_mv |
AT orfanoudakimaria cytotoxiccompoundsoftwodemospongesaplysinaaerophobaandspongiaspfromtheaegeansea |
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1787740843589763072 |