A study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents
The sample data shown in Table 1 reflects drug-diluent binary mixture compacted at variable compaction forces but with the same punch tooling. The tested validity of Pitts model has shown a w/d ≥ 2.0 which was above the theoretical minimum acceptable value of 1.0. The shape factors decrease with inc...
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| Ngôn ngữ: | en_US |
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2023
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| Truy cập trực tuyến: | http://tailieuso.tlu.edu.vn/handle/DHTL/12869 |
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oai:localhost:DHTL-128692023-03-31T07:48:33Z A study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents Salim, Ilyasu Olowosulu, Adeniji Kehinde Abdulsamad, Abdulrahman Coprocessed diluents Dilution potential Mechanical strength Tensile strength Shape factors Biconvex tablets Polynomial regression The sample data shown in Table 1 reflects drug-diluent binary mixture compacted at variable compaction forces but with the same punch tooling. The tested validity of Pitts model has shown a w/d ≥ 2.0 which was above the theoretical minimum acceptable value of 1.0. The shape factors decrease with increasing values of d, t, and w. Previous studies found only slight differences between the shape factors, however with ΦSh being slightly higher (Yohannes and Abebe 2021). Comparing the shape factors for the three models in this study, it was observed that ΦPt was slightly higher than ΦPz, but ΦSh differ significantly to as twice their values. Tukey’s multiple comparison test indicated statistically significant differences between the three shape factors (p < 0.05) (Table 2). The variability can be appreciated when both ΦSh and ΦPt were normalized with ΦPz. The shape factors ΦSh and ΦPt were higher than ΦPz by a factor of 2.4 and 1.2, respectively. Similar trend holds for all other compaction data. https://link.springer.com/article/10.1186/s42269-022-00860-7 2023-03-31T07:48:33Z 2023-03-31T07:48:33Z 2022 BB 2522-8307 http://tailieuso.tlu.edu.vn/handle/DHTL/12869 en_US Bulletin of the National Research Centre, Volume 46 (2022), Article number: 173 |
| institution |
Trường Đại học Thủy Lợi |
| collection |
DSpace |
| language |
en_US |
| topic |
Coprocessed diluents Dilution potential Mechanical strength Tensile strength Shape factors Biconvex tablets Polynomial regression |
| spellingShingle |
Coprocessed diluents Dilution potential Mechanical strength Tensile strength Shape factors Biconvex tablets Polynomial regression Salim, Ilyasu A study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents |
| description |
The sample data shown in Table 1 reflects drug-diluent binary mixture compacted at variable compaction forces but with the same punch tooling. The tested validity of Pitts model has shown a w/d ≥ 2.0 which was above the theoretical minimum acceptable value of 1.0. The shape factors decrease with increasing values of d, t, and w. Previous studies found only slight differences between the shape factors, however with ΦSh being slightly higher (Yohannes and Abebe 2021). Comparing the shape factors for the three models in this study, it was observed that ΦPt was slightly higher than ΦPz, but ΦSh differ significantly to as twice their values. Tukey’s multiple comparison test indicated statistically significant differences between the three shape factors (p < 0.05) (Table 2). The variability can be appreciated when both ΦSh and ΦPt were normalized with ΦPz. The shape factors ΦSh and ΦPt were higher than ΦPz by a factor of 2.4 and 1.2, respectively. Similar trend holds for all other compaction data. |
| author2 |
Olowosulu, Adeniji Kehinde |
| author_facet |
Olowosulu, Adeniji Kehinde Salim, Ilyasu |
| format |
BB |
| author |
Salim, Ilyasu |
| author_sort |
Salim, Ilyasu |
| title |
A study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents |
| title_short |
A study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents |
| title_full |
A study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents |
| title_fullStr |
A study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents |
| title_full_unstemmed |
A study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents |
| title_sort |
study on the effect of biconvex compact shape factors on prediction of dilution potential from tensile strength–compaction force data of coprocessed diluents |
| publishDate |
2023 |
| url |
http://tailieuso.tlu.edu.vn/handle/DHTL/12869 |
| work_keys_str_mv |
AT salimilyasu astudyontheeffectofbiconvexcompactshapefactorsonpredictionofdilutionpotentialfromtensilestrengthcompactionforcedataofcoprocesseddiluents AT salimilyasu studyontheeffectofbiconvexcompactshapefactorsonpredictionofdilutionpotentialfromtensilestrengthcompactionforcedataofcoprocesseddiluents |
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