Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica
Bioactivity-guided chromatographic fractionation was performed on the endophytic extract and resulted in the identification of asperazine and asperazine A through spectroscopic analysis. Moderate cytotoxicity against HeLa cell lines (CC50 = 18.4 µg mL−1) and moderate antiproliferative effects agains...
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| Định dạng: | BB |
| Ngôn ngữ: | en_US |
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2023
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| Truy cập trực tuyến: | http://tailieuso.tlu.edu.vn/handle/DHTL/12415 |
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oai:localhost:DHTL-124152023-03-16T07:24:30Z Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica Abdou, Randa Alqahtani, Alaa M. Attia, Gouda H. Asperazine Asperazine A Aspergillus neoniger Ficus carica Endophyte Bioactivity-guided chromatographic fractionation was performed on the endophytic extract and resulted in the identification of asperazine and asperazine A through spectroscopic analysis. Moderate cytotoxicity against HeLa cell lines (CC50 = 18.4 µg mL−1) and moderate antiproliferative effects against HUVEC and K-562 cell lines (GI50 = 31.5 and 24.8 µg mL−1, respectively) were observed for asperazine. Asperazine A on the other hand showed weak cytotoxic activity against HeLa cell lines (CC50 = 34.6 µg mL−1) as well as weak cytostatic activities against HUVEC and K-562 cell lines (GI50 = 40.7 and 50.2 µg mL−1, respectively) while no antimicrobial activity was detected for both compounds. https://link.springer.com/article/10.1186/s42269-021-00536-8 2023-03-16T07:24:30Z 2023-03-16T07:24:30Z 2021 BB 2522-8307 http://tailieuso.tlu.edu.vn/handle/DHTL/12415 en_US Bulletin of the National Research Centre, Volume 45 (2021), Article number: 74 |
| institution |
Trường Đại học Thủy Lợi |
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en_US |
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Asperazine Asperazine A Aspergillus neoniger Ficus carica Endophyte |
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Asperazine Asperazine A Aspergillus neoniger Ficus carica Endophyte Abdou, Randa Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica |
| description |
Bioactivity-guided chromatographic fractionation was performed on the endophytic extract and resulted in the identification of asperazine and asperazine A through spectroscopic analysis. Moderate cytotoxicity against HeLa cell lines (CC50 = 18.4 µg mL−1) and moderate antiproliferative effects against HUVEC and K-562 cell lines (GI50 = 31.5 and 24.8 µg mL−1, respectively) were observed for asperazine. Asperazine A on the other hand showed weak cytotoxic activity against HeLa cell lines (CC50 = 34.6 µg mL−1) as well as weak cytostatic activities against HUVEC and K-562 cell lines (GI50 = 40.7 and 50.2 µg mL−1, respectively) while no antimicrobial activity was detected for both compounds. |
| author2 |
Alqahtani, Alaa M. |
| author_facet |
Alqahtani, Alaa M. Abdou, Randa |
| format |
BB |
| author |
Abdou, Randa |
| author_sort |
Abdou, Randa |
| title |
Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica |
| title_short |
Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica |
| title_full |
Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica |
| title_fullStr |
Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica |
| title_full_unstemmed |
Anticancer natural products from Aspergillus neoniger, an endophyte of Ficus carica |
| title_sort |
anticancer natural products from aspergillus neoniger, an endophyte of ficus carica |
| publishDate |
2023 |
| url |
http://tailieuso.tlu.edu.vn/handle/DHTL/12415 |
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AT abdouranda anticancernaturalproductsfromaspergillusneonigeranendophyteofficuscarica |
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