Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide
The results showed that MEAC induced an inhibitory effect against chromosomal aberrations of CP in mouse bone marrow and spermatocytes. Such effect was found to be significant (p < 0.01) with a dose of 100 mg/kg treated once for 24 h and also after repeated treatment at a dose of 25 mg/kg for 7 d...
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| Ngôn ngữ: | English |
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2022
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| Truy cập trực tuyến: | http://tailieuso.tlu.edu.vn/handle/DHTL/11663 |
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oai:localhost:DHTL-116632022-01-10T02:18:24Z Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide Nabil, Marian Hassan, Entesar E. Ghaly, Neven S. Aly, Fawzia A. Melek, Farouk R. Hassan, Zeinab M. Fahmy, Maha A. Farghaly, Ayman A. Cyclophosphamide Bark extract Anti-genotoxicity Chromosomal abnormalities Sperm defects The results showed that MEAC induced an inhibitory effect against chromosomal aberrations of CP in mouse bone marrow and spermatocytes. Such effect was found to be significant (p < 0.01) with a dose of 100 mg/kg treated once for 24 h and also after repeated treatment at a dose of 25 mg/kg for 7 days. In sperm abnormalities, the protective effect of Albizia extract showed a dose-related relationship. Different doses of MEAC (25, 50, and 100 mg/kg) significantly (p < 0.01) ameliorated sperm abnormalities induced by CP dose-dependently. The percentage of sperm abnormalities was decreased to 5.14 ± 0.72 in the group of animals treated with CP plus MEAC (100 mg/kg) indicating an inhibitory effect of about 50%. https://bnrc.springeropen.com/articles/10.1186/s42269-020-00422-9 2022-01-10T02:18:24Z 2022-01-10T02:18:24Z 2020 BB 2522-8307 http://tailieuso.tlu.edu.vn/handle/DHTL/11663 en Bulletin of the National Research Centre, Volume 44 (2020), Article number: 165 |
| institution |
Trường Đại học Thủy Lợi |
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DSpace |
| language |
English |
| topic |
Cyclophosphamide Bark extract Anti-genotoxicity Chromosomal abnormalities Sperm defects |
| spellingShingle |
Cyclophosphamide Bark extract Anti-genotoxicity Chromosomal abnormalities Sperm defects Nabil, Marian Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide |
| description |
The results showed that MEAC induced an inhibitory effect against chromosomal aberrations of CP in mouse bone marrow and spermatocytes. Such effect was found to be significant (p < 0.01) with a dose of 100 mg/kg treated once for 24 h and also after repeated treatment at a dose of 25 mg/kg for 7 days. In sperm abnormalities, the protective effect of Albizia extract showed a dose-related relationship. Different doses of MEAC (25, 50, and 100 mg/kg) significantly (p < 0.01) ameliorated sperm abnormalities induced by CP dose-dependently. The percentage of sperm abnormalities was decreased to 5.14 ± 0.72 in the group of animals treated with CP plus MEAC (100 mg/kg) indicating an inhibitory effect of about 50%. |
| author2 |
Hassan, Entesar E. |
| author_facet |
Hassan, Entesar E. Nabil, Marian |
| format |
BB |
| author |
Nabil, Marian |
| author_sort |
Nabil, Marian |
| title |
Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide |
| title_short |
Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide |
| title_full |
Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide |
| title_fullStr |
Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide |
| title_full_unstemmed |
Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide |
| title_sort |
albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide |
| publishDate |
2022 |
| url |
http://tailieuso.tlu.edu.vn/handle/DHTL/11663 |
| work_keys_str_mv |
AT nabilmarian albiziachinensisbarkextractamelioratesthegenotoxiceffectofcyclophosphamide |
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