Ameliorating effect of gum arabic and lemongrass on chronic kidney disease induced experimentally in rats
Compared to control group, adenine-injected rats had significantly higher levels of serum urea, creatinine, and uric acid. Moreover, biochemical analysis of kidney homogenate showed that adenine injection was associated with significantly higher levels of malondialdehyde and lower levels of reduced...
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| Định dạng: | BB |
| Ngôn ngữ: | English |
| Thông tin xuất bản: |
2021
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| Chủ đề: | |
| Truy cập trực tuyến: | http://tailieuso.tlu.edu.vn/handle/DHTL/10673 |
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| Tóm tắt: | Compared to control group, adenine-injected rats had significantly higher levels of serum urea, creatinine, and uric acid. Moreover, biochemical analysis of kidney homogenate showed that adenine injection was associated with significantly higher levels of malondialdehyde and lower levels of reduced glutathione and antioxidant enzyme activities in comparison with normal control. Additionally, the adenine group exhibited a significant upregulation in tumor necrosis factor-α and downregulation in interleukin-10 gene expression. Histopathological and immunohistochemical examinations of renal tissue from the adenine group showed degeneration to renal glomeruli and renal tubules with increased DNA double-strand breaks. On the other hand, treatment with GA or LG ameliorated all the previous parameters to a large extent. |
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