Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis

The etiology and pathophysiology of inflammatory bowel disease (IBD), which is a multifactorial disorder, remain poorly understood. Curcuma longa extract has been demonstrated to exhibit anti-inflammatory activity in the literature. Here, we examined the effect of C. longa extract on dextran sulfate...

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Tác giả chính:	Bui, Thanh Tung, Nguyen, Thanh Hai, Le, Thi Thu Huong, Duong, Thi Ly Huong
Định dạng:	Bài trích
Ngôn ngữ:	English
Thông tin xuất bản:	Merit Research Journal of Medicine and Medical Sciences 2016
Chủ đề:	Curcuma longa extract Colitis DSS Inflammation Mice
Truy cập trực tuyến:	http://repository.vnu.edu.vn/handle/VNU_123/11205
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spelling	oai:112.137.131.14:VNU_123-112052018-07-10T03:22:12Z Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis Bui, Thanh Tung Nguyen, Thanh Hai Le, Thi Thu Huong Duong, Thi Ly Huong Curcuma longa extract Colitis DSS Inflammation Mice The etiology and pathophysiology of inflammatory bowel disease (IBD), which is a multifactorial disorder, remain poorly understood. Curcuma longa extract has been demonstrated to exhibit anti-inflammatory activity in the literature. Here, we examined the effect of C. longa extract on dextran sulfate sodium (DSS)-induced colitis over a period of 7 days. The extract (150 mg/kg/b.w.) was mixed with the diet of the mice. C. longa significantly reduced the Disease Activity Index and myeloperoxidase activity. The extract also suppressed the levels of pro-inflammatory IL-1β, IL-6, IL-17, INFγ, TNF-α and increased the level of IL-10. Additionally, the protein expression levels of COX-2 and iNOS were reduced by C. longa extract. Our results suggest that C. longa extract exerts beneficial effects on experimental colitis; therefore, we propose that this extract may have therapeutic implications for ulcerative colitis. School of Medicine and Pharmacy,Vietnam National University, Hanoi 2016-05-29T03:47:40Z 2016-05-29T03:47:40Z 2014 Article Bui, T. T. et al. (2004). Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis. Journal of Medicine and Medical Sciences, 2 (10), 216-224 2354-323X http://repository.vnu.edu.vn/handle/VNU_123/11205 en Journal of Medicine and Medical Sciences © 2014 Merit Research Journals application/pdf Merit Research Journal of Medicine and Medical Sciences
institution	Đại học Quốc Gia Hà Nội
collection	DSpace
language	English
topic	Curcuma longa extract Colitis DSS Inflammation Mice
spellingShingle	Curcuma longa extract Colitis DSS Inflammation Mice Bui, Thanh Tung Nguyen, Thanh Hai Le, Thi Thu Huong Duong, Thi Ly Huong Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis
description	The etiology and pathophysiology of inflammatory bowel disease (IBD), which is a multifactorial disorder, remain poorly understood. Curcuma longa extract has been demonstrated to exhibit anti-inflammatory activity in the literature. Here, we examined the effect of C. longa extract on dextran sulfate sodium (DSS)-induced colitis over a period of 7 days. The extract (150 mg/kg/b.w.) was mixed with the diet of the mice. C. longa significantly reduced the Disease Activity Index and myeloperoxidase activity. The extract also suppressed the levels of pro-inflammatory IL-1β, IL-6, IL-17, INFγ, TNF-α and increased the level of IL-10. Additionally, the protein expression levels of COX-2 and iNOS were reduced by C. longa extract. Our results suggest that C. longa extract exerts beneficial effects on experimental colitis; therefore, we propose that this extract may have therapeutic implications for ulcerative colitis.
format	Article
author	Bui, Thanh Tung Nguyen, Thanh Hai Le, Thi Thu Huong Duong, Thi Ly Huong
author_facet	Bui, Thanh Tung Nguyen, Thanh Hai Le, Thi Thu Huong Duong, Thi Ly Huong
author_sort	Bui, Thanh Tung
title	Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis
title_short	Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis
title_full	Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis
title_fullStr	Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis
title_full_unstemmed	Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis
title_sort	curcuma longa extract suppresses inflammation in mice with dss-induced acute colitis
publisher	Merit Research Journal of Medicine and Medical Sciences
publishDate	2016
url	http://repository.vnu.edu.vn/handle/VNU_123/11205
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Curcuma longa extract suppresses inflammation in mice with DSS-induced acute colitis

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